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DRα1-mMOG-35-55 treatment efficacy of chronic EAE in female mice depends on the expression of ERα. EAE daily scores of ERα-KO (ERKO) and ERβ-KO (BERKO) female mice treated with 100 μg DRα1-mMOG-35-55 or vehicle (injection days indicated by black arrows) and mean clinical EAE daily disease scores (left) and cumulative disease index scores (right) are shown. *p ≤ 0.05. Daily mean scores were analyzed by Mann-Whitney U and mean CDI by Student’s t test
