Table 2.

IC₅₀ of compounds 1–20 isolated from A. iwayomogi on aldose reductase (AR) and advanced glycation endproducts (AGEs) formation.

Compound	IC50a (μM)
	AR	AGEs formation
1	90.39 ± 1.91∗∗	20.71 ± 1.38∗∗
2	131.37 ± 0.12∗	82.43 ± 1.52∗∗
3	>200	311.89 ± 11.26∗∗
4	2.93 ± 0.11∗∗	185.56 ± 0.20∗∗
5	110.65 ± 9.89∗∗	169.61 ± 16.41∗∗
6	30.29 ± 3.95∗	134.88 ± 0.84∗∗
7	102.53 ± 7.81∗∗	207.70 ± 13.32∗∗
8	3.19 ± 0.10∗∗	197.38 ± 11.03∗∗
9	3.32 ± 0.21∗∗	67.42 ± 9.95∗∗
10	10.60 ± 0.38∗∗	109.46 ± 1.41∗∗
11	12.53 ± 0.20∗∗	129.15 ± 4.01∗∗
12	4.54 ± 0.16∗∗	176.16 ± 5.77∗∗
13	0.22 ± 0.01∗∗	24.85 ± 1.86∗∗
14	1.90 ± 0.01∗∗	124.28 ± 4.25∗∗
15	1.25 ± 0.01∗∗	31.78 ± 0.56∗∗
16	1.48 ± 0.04∗∗	44.45 ± 4.86∗∗
17	>200	NDd
18	>200	NDd
19	>200	NDd
20	>200	1048.99 ± 0.11∗
TMGb	6.58 ± 0.19∗	—
AGc	—	414.77 ± 5.96∗

^aIC₅₀ calculated from the least-squares regression line of the logarithmic concentrations plotted against the residual activity.

^bTMG was used as a positive control.

^cAG was used as a positive control.

^dND was not detected.

^∗Significant difference from control; ^∗p < 0.05, ^∗∗p < 0.01.