Table 2.
Median (25th, 75th percentile) weighted concentrations of inflammation and oxidative stress biomarkers and specific gravity at visit 1 of pregnancy (median gestational age=10 weeks).
| Normotensive pregnancy (n=391) | Preeclamptic pregnancy (n=50) | ||||
|---|---|---|---|---|---|
| Plasma inflammation biomarkers | N | Median (25th, 75th percentile) | N | Median (25th, 75th percentile) | p-value |
| C-reactive protein (µg/mL) | 336 | 3.91 (2.13, 8.44) | 44 | 7.85 (3.82, 16.8) | 0.05 |
| IL-1β (pg/mL) | 336 | 0.29 (0.17, 0.52) | 44 | 0.28 (0.14, 0.61) | 0.44 |
| IL-6 (pg/mL) | 336 | 1.31 (0.78, 2.42) | 44 | 1.33 (0.76, 3.38) | 0.70 |
| IL-10 (pg/mL) | 336 | 12.5 (8.62, 19.3) | 44 | 14.6 (9.68, 21.8) | 0.29 |
| TNF-α (pg/mL) | 336 | 2.85 (2.04, 3.87) | 44 | 3.35 (2.68, 4.22) | <0.01 |
| Urinary oxidative stress biomarkers | |||||
| 8-hydroxydeoxyguanosine (ng/mL) | 381 | 128 (64.0, 206) | 50 | 113 (79.8, 216) | 0.85 |
| 8-isoprostane (ng/mL) | 383 | 211 (99.5, 372) | 50 | 369 (240, 522) | 0.04 |
| Specific gravity (no units) | 390 | 1.016 (1.010, 1.023) | 50 | 1.019 (1.012, 1.025) | 0.07 |