Table 3.

Hazard ratios (HR) of preeclampsia and 95% confidence intervals (CIs) in association with an interquartile range difference in inflammation biomarker.

	Average of visits 1–3		Visit 1		Visit 2		Visit 3		Visit 4
Model 1	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
CRP	2.01 (1.52, 2.65)	<0.01	1.45 (1.15, 1.83)	<0.01	2.15 (1.64, 2.83)	<0.01	1.50 (1.12, 2.01)	0.01	1.01 (0.74, 1.37)	0.96
IL-1β	1.22 (1.02, 1.45)	0.03	1.13 (0.93, 1.37)	0.21	1.33 (1.13, 1.57)	<0.01	1.23 (1.02, 1.48)	0.03	1.28 (1.07, 1.53)	0.01
IL-6	1.26 (1.07, 1.48)	0.01	1.08 (0.91, 1.28)	0.38	1.33 (1.14, 1.56)	<0.01	1.41 (1.15, 1.71)	<0.01	1.23 (1.01, 1.50)	0.04
IL-10	1.23 (1.03, 1.46)	0.02	1.16 (0.98, 1.38)	0.08	1.31 (1.11, 1.55)	<0.01	1.33 (1.08, 1.64)	0.01	1.16 (0.95, 1.42)	0.14
TNF-α	1.70 (1.43, 2.02)	<0.01	1.61 (1.34, 1.93)	<0.01	1.60 (1.33, 1.91)	<0.01	1.71 (1.42, 2.06)	<0.01	1.74 (1.42, 2.12)	<0.01
Model 2
CRP	1.43 (1.04, 1.96)	0.03	1.08 (0.83, 1.42)	0.56	1.83 (1.33, 2.51)	<0.01	1.25 (0.90, 1.73)	0.18	0.79 (0.59, 1.06)	0.11
IL-1β	1.16 (0.98, 1.37)	0.09	1.10 (0.91, 1.32)	0.34	1.31 (1.12, 1.54)	<0.01	1.17 (0.97, 1.42)	0.10	1.20 (1.00, 1.44)	0.05
IL-6	1.19 (0.97, 1.46)	0.09	0.94 (0.76, 1.18)	0.62	1.32 (1.09, 1.59)	<0.01	1.36 (1.09, 1.69)	0.01	1.21 (0.95, 1.55)	0.13
IL-10	1.30 (1.06, 1.60)	0.01	1.21 (0.99, 1.48)	0.06	1.40 (1.16, 1.68)	<0.01	1.35 (1.08, 1.70)	0.01	1.20 (0.94, 1.53)	0.14
TNF-α	1.59 (1.30, 1.94)	<0.01	1.49 (1.22, 1.83)	<0.01	1.50 (1.23, 1.84)	<0.01	1.65 (1.33, 2.04)	<0.01	1.63 (1.3, 2.04)	<0.01

Model 1 unadjusted for covariates. Model 2 adjusted for maternal race/ethnicity and body mass index at visit 1.Sample sizes for model 1 (preeclamptic and normotensive pregnancies): Average (49, 390); Visit 1 (44, 336); Visit 2 (43, 324); Visit 3 (40, 313); Visit 4 (32, 312). Sample sizes for model 2 (preeclamptic and normotensive pregnancies): Average (49, 387); Visit 1 (44, 333); Visit 2 (43, 323); Visit 3 (40, 312); Visit 4 (32, 309).