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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Feb 28;234(9-10):1573–1586. doi: 10.1007/s00213-017-4572-2

Figure 3.

Figure 3

Effects of chronic nicotine (“low” 14 or “high 40” mg/kg/day v. saline) administration and withdrawal on performance of WT and α7 nAChR KO mice in the 5C-CPT. Thirty-three days after nicotine minipump implantation (“Nicotine”), there were no main effects of nicotine treatment or genotype on d′ (a), p[HR] (b), p[FA] (c), RI (d), and MCL (f). There was a significant nicotine × genotype interaction on p[HR] (b), since WT but not KO mice receiving the low dose of nicotine exhibited elevated p[HR]. Four h after pump removal (“Withdrawal”), there were no main effects of nicotine treatment or genotype nor nicotine × genotype interactions on p[HR], RI, or MCL. After pump removal, there was a main effect of withdrawal from nicotine treatment on p[FA] (c), and there was a trend toward an effect of nicotine withdrawal on d′ (a) whereby the effect of nicotine withdrawal to decrease d′ was significant for WT but not KO mice. During and after nicotine treatment, there was a main effect of genotype on accuracy (d) with KO mice exhibiting lower accuracy than WT littermates. Data are shown as mean ± SEM, #p<0.1, *p<0.05 when compared with saline.