Table 2.

Performance of different proteins as early-detection plasma markers

	CHS plasma samples					EDRN plasma samples
Proteins	OR	p	Q	AUC	Sens	OR	p	q	AUC	Sens
BAG4	0.642	0.001	0.174	0.66	32.1%	0.940	1.89E-08	0.003	0.78	54.2%
PIK3CA	0.519	0.001	0.174	0.66	27.8%	0.456	0.010	0.014	0.65	25.0%
EGFR	0.380	0.012	0.191	0.63	25.6%	0.429	0.001	0.004	0.71	34.5%
VWF	0.338	0.011	0.191	0.62	25.0%	0.419	0.042	0.035	0.61	19.5%
UBE2S	0.419	0.003	0.182	0.64	22.8%	0.669	2.61E-04	0.003	0.67	41.1%
VIP	0.498	0.002	0.176	0.64	22.1%	1.043	1.02E-07	0.003	0.79	48.3%
CC2D1A	0.408	0.012	0.191	0.62	20.8%	0.757	2.86E-06	0.003	0.75	38.7%
PHB	0.419	0.014	0.198	0.62	20.5%	0.377	0.013	0.016	0.61	22.1%
ERCC5	0.451	0.007	0.191	0.62	19.7%	0.698	4.34E-04	0.003	0.65	29.7%
CD44	0.462	0.005	0.191	0.63	19.2%	0.357	0.037	0.032	0.62	21.0%
RAB7L1	0.348	0.009	0.191	0.61	19.0%	0.619	0.001	0.004	0.66	20.3%
LYPD1	0.434	0.002	0.176	0.64	18.4%	0.384	0.005	0.009	0.63	22.5%
ANKRD6	0.393	0.012	0.191	0.61	18.2%	0.483	0.011	0.015	0.66	23.4%
IL6ST	0.483	0.015	0.205	0.61	18.1%	0.654	0.015	0.018	0.70	20.4%
CD4	0.383	0.013	0.191	0.61	17.9%	0.415	0.010	0.014	0.63	10.2%
CHEK1	0.379	0.009	0.191	0.61	17.7%	0.525	0.001	0.005	0.71	35.8%
MAPK1	0.373	0.006	0.191	0.62	16.9%	0.703	0.008	0.012	0.62	23.5%
BRCA1	0.408	0.007	0.191	0.60	16.7%	0.599	0.003	0.006	0.70	35.2%
GRB2	0.445	0.011	0.191	0.62	16.7%	0.426	0.016	0.018	0.64	28.9%
MSMB	0.457	0.005	0.191	0.64	16.7%	0.394	0.020	0.021	0.60	17.5%
FLT3	0.370	0.008	0.191	0.63	15.4%	0.409	0.008	0.012	0.69	26.9%
BIRC3	0.478	0.002	0.174	0.65	14.1%	0.510	0.003	0.006	0.68	32.2%
BTG1	0.419	0.007	0.191	0.64	14.1%	0.618	0.001	0.004	0.68	39.5%
FN1 (Ab2)	0.424	0.012	0.191	0.63	13.9%	0.430	0.015	0.018	0.64	16.9%
PRL	0.445	0.006	0.191	0.63	13.9%	0.760	8.54E-05	0.003	0.74	37.3%
WDR1	0.469	0.002	0.174	0.65	13.9%	0.499	0.001	0.004	0.65	17.2%
SPP1	0.416	0.011	0.191	0.63	13.9%	0.547	0.004	0.008	0.66	31.9%
FN1 (Ab1)	0.427	0.006	0.191	0.64	13.0%	0.451	0.007	0.011	0.72	34.8%
GRN	0.400	0.010	0.191	0.64	13.0%	0.446	0.001	0.004	0.70	42.1%
NAIP	0.410	0.008	0.191	0.63	13.0%	0.375	0.027	0.026	0.61	12.1%
SV2A	0.405	0.004	0.191	0.65	10.4%	0.608	0.001	0.003	0.71	37.4%
HOXA3	0.429	0.005	0.191	0.65	9.2%	0.444	0.015	0.018	0.65	17.9%

Of the 78 markers that met the performance criteria of positive odds ratio (OR), p≤0.015, and AUC>0.60 in the Cardiovascular Health Study (CHS) prediagnostic samples, the 32 listed here met our confirmation criteria of a positive OR, p<0.05, and AUC>0.60 in the EDRN samples (120 cases consisting of 30 adenomas, 30 advanced adenomas, 30 stage I–II cancers, 30 stage III–IV cancers and 60 healthy controls). The q-value corrects for multiple comparison testing. Sens = sensitivity at 90% specificity. See Supplementary Table S3 for M value data.