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editorial
. 2017 Apr 14;4:28. doi: 10.21037/sci.2017.04.02

Figure 1.

Figure 1

Physiological and pathological effects of PDGFR signalling activation. PDGFA acts on adipose progenitors (CD24+) resident in the skin to stimulate their proliferation and self-renewal. The role of this pathway in the adipocyte-myofibroblast transition in white adipose tissue has also been described. PDGFA also acts on fibro-adipogenic progenitor (PDGFRa+) resident in skeletal muscles to both participate to muscle regeneration of healthy tissue and to be responsible to fibrosis if muscle diseases.