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. 2017 May 8;11:131. doi: 10.3389/fncel.2017.00131

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Copyright © 2017 Cao, Hu, Xu, Zhang, Li and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human iPSCs-derived serotonergic neurons migrate and project to the host’s cerebellum, hindbrain and spinal cord in vivo. (A–C) After 3 months of transplantation, human serotonergic neurons formed chimera with the host’s brain tissues around the 4th brain ventricle. (B) is the detailed image for inset 1 in (A); (C) is the detailed image for inset 2 in (A). (D) Serotonin+ human fibers were observed in the host’s cerebellum. (E) Serotonin+ human cell bodies were observed in the host’s ventral hindbrain. (F) Serotonin+ human fibers were observed in the host’s spinal cord. Scale bar: (A) 200 μm; (B–F), 50 μm; Red: Serotonin+ cells; Green: STEM121+ cells (human cells); Blue: Hoechst staining (Ho).