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. 2017 May 8;11:83. doi: 10.3389/fnbeh.2017.00083

Figure 1.

Figure 1

Effects of orexin-2 (OX2R) inhibition on cage exchange (CE) stress-induced adrenocorticotropic hormone (ACTH) release in mice. ACTH levels were measured in non-treated OX2R knockout (KO; n = 12) and wild-type (WT; n = 13) mice under baseline (A) and CE or control (Cont) conditions (B), and in treated mice orally dosed 30 min prior to CE or Cont procedure with the OX2R antagonist JNJ-42847922 (30 mg/kg) or vehicle (n = 21–25 animals per condition) (C) and with the dual OX1/2R antagonist SB-649868 (30 mg/kg) or vehicle (n = 15–18 animals per condition) (D). Individual values of ACTH and means (± SEM) are expressed in pg/ml of serum. Statistical significance (*p < 0.05, **p < 0.01 and ***p < 0.001) was based on one-way analysis of variance (ANOVA) followed by a Tukey’s multiple comparison post hoc test.