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. 2017 May 8;11:83. doi: 10.3389/fnbeh.2017.00083

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Copyright © 2017 Yun, Wennerholm, Shelton, Bonaventure, Letavic, Shireman, Lovenberg and Dugovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential effects of OX2R and dual OX1/2R antagonism on non-rapid eye movement (NREM) and REM sleep in mice. NREM sleep latencies (A,E) and durations (B,F) and REM sleep latencies (C,G) and durations (D,H) after oral dosing with the OX2R antagonist JNJ-42847922 (30 mg/kg) or vehicle (n = 7 animals per condition; left panel) and with the dual OX1/2R antagonist SB-649868 (30 mg/kg) or vehicle (n = 7 animals per condition; right panel) are represented as means (± SEM) and are expressed in minutes. **p < 0.01 and ***p < 0.001 vs. vehicle, based on a paired Student’s t test for NREM and REM sleep latencies or a two-way repeated measures ANOVA (interaction Time × Treatment) followed by a Bonferroni post hoc test for NREM and REM sleep durations.