Figure 7.

Modulation of coupling index (CP) of reentry in atrial fibrillation by intersubject variability in action potential phenotype in response to ion channel block. Dorsal views of the left atrium (left) and right atrium (right) are shown. CP between electrogram in adjacent electrodes (thick white lines represent CP > 0.9, thin solid lines represent 0.75 ≤ CP < 0.9, and soft gray lines represent 0.6 ≤ CP < 0.75. CP < 0.6 is represented by absence of lines) for short and long APD₉₀, APD₅₀, and APD₂₀ subpopulations of models before (default) and after 30% I_K1 inhibition, 30% I_NaK inhibition, and 15% I_Na inhibition, respectively.