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. 2017 May 8;11:252. doi: 10.3389/fnins.2017.00252

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Copyright © 2017 Zhang, Tu, Wang, Cao, Muelleman, Wadman and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vagal control of ventricular function measured by changes of left ventricular systolic pressure (LVSP) in response to different frequencies of left vagal efferent nerve stimulation in anesthetized sham and CHF rats. (A) Representative recordings demonstrating change of LVSP in response to 20 Hz of left vagal efferent nerve stimulation in 14-week sham and CHF rats. (B,C) Quantitative data for changes of LVSP and LV dP/dt_max in response to different frequencies (1–100 Hz) of left vagal efferent nerve stimulation in 3, 8, and 14-week sham and CHF rats. Data are mean ± SEM; n = 5 rats in each group. ^*P < 0.05 vs. age-matched sham rats.