Table 1.
Hemodynamic and morphological characteristics in anesthetized sham and CHF rats.
| Sham | CHF | |||||
|---|---|---|---|---|---|---|
| 3-weeks | 8-weeks | 14-weeks | 3-weeks | 8-weeks | 14-weeks | |
| MAP (mmHg) | 101.4 ± 4.0 | 103.8 ± 4.6 | 102.8 ± 4.4 | 103.2 ± 4.4 | 102.4 ± 4.3 | 104.2 ± 4.9 |
| Infarct size (% of LV) | 0 | 0 | 0 | 37.4 ± 2.2* | 39.0 ± 3.1* | 38.2 ± 2.1* |
| LVSP (mmHg) | 121.8 ± 3.9 | 122.6 ± 3.8 | 122.8 ± 3.4 | 115.2 ± 4.2* | 112.2 ± 4.6* | 101.2 ± 3.7* |
| LV dP/dtmax (mmHg/s) | 6165 ± 278 | 6023 ± 274 | 6132 ± 241 | 5605 ± 244 | 5249 ± 228* | 4894 ± 287* |
| LVEDP (mmHg) | 2.1 ± 0.4 | 2.0 ± 0.4 | 2.3 ± 0.4 | 17.0 ± 0.7* | 17.6 ± 1.1* | 18.4 ± 1.5* |
CHF, chronic heart failure; MAP, mean arterial pressure; LVSP, left ventricular systolic pressure; LV dP/dtmax, the maximum rate of left ventricular pressure rise; LVEDP, left ventricular end-diastolic pressure. Data are means ± SEM; n = 5 in each group.
*
P < 0.05 vs. age-matched sham rats.