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. 2017 Apr 14;49(4):e315. doi: 10.1038/emm.2017.2

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Copyright © 2017 The Author(s)

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TRNs delineating the pluripotency-related processes during the reprogramming of SSCs to mSSCs. (a–c) TRNs underlying the regulation of the genes involved in pluripotency-related processes— stem cell maintenance (a), cell proliferation-related processes (b) and epigenetic regulation (c). The node shapes represent DE-mTFs (diamond) and target genes (circles) and the node colors represent the groups that include the nodes (see node legend box at the bottom). The arrows represent TF-target gene relationships, and the dotted lines represent Protein–protein interactions. The same colors were used for the TFs and the arrow edges. The nodes in the three TRNs were arranged according to the KEGG pathways associated with the three pluripotency-related processes. On the basis of the KEGG pathways, +p and −p represent phosphorylation and dephosphorylation reactions, respectively, and the suppression symbols denote the repression reactions. The background represents a network module that includes the nodes involved in the corresponding cellular process.