Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 26;4(5):326–339. doi: 10.1002/acn3.413

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Screening anticonvulsant response using spontaneous seizure monitoring following hyperthermia‐priming in Scn1a ^+/− mice. GTCS frequency of individual untreated and drug‐treated mice (n = 13–18 mice per treatment group). Drug treatment was initiated following the induction of a single hyperthermia‐induced seizure. Unprovoked, spontaneous GTCS were subsequently quantified over a 60‐hour recording period. Clobazam treatment significantly reduced the proportion of mice experiencing GTCS (*P < 0.046, Fisher's exact test). The untreated cohort represented by black, open symbols, and gray shading are naïve controls to demonstrate the significant difference between naïve and hyperthermia‐priming (black, closed circles) seizure incidences (P < 0.041, Fisher's exact test).