Figure 8.

Combination therapy with clobazam and stiripentol in Scn1a ^+/− mice. (A) Dose‐response curve for seizure protection in hyperthermia‐induced seizure threshold testing. Scn1a ^+/− mice treated with varying doses of clobazam and 25 mg/kg of stiripentol resulted in a left‐shift of the EC ₅₀ compared to clobazam‐only treated mice (n = 8–17 mice per treatment group). (B) The percentage of untreated, clobazam only, and clobazam plus stiripentol‐treated mice that did not have spontaneous GTCS during the 60‐hour recording period. Drug treatment was initiated following the induction of a single hyperthermia‐induced seizure (n = 16–25 mice per treatment group). (C) Average clobazam and N‐desmethylclobazam plasma concentrations of Scn1a ^+/− mice treated subchronically with clobazam‐only or clobazam plus stiripentol. The combination treatment resulted in higher clobazam and N‐desmethylclobazam plasma levels (n = 6–7 mice per treatment group, error bars represent SEM). (**P < 0.004).