Table 3.
Adjusted Analyses of Patient-Reported Outcomes 2 Weeks and 3 Months After Hematopoietic Stem Cell Transplantationa
| Outcomes | Sample Size, No. | Adjusted Mean Score (95% CI) | Adjusted Mean Difference Between Groups (95% CI) | P Value |
|---|---|---|---|---|
| At 2 weeks | ||||
| FACT-BMT score (primary outcome) | ||||
| Standard care | 77 | 86.60 (82.00–91.20) | 7.73 (1.27 to 14.19) | .02 |
| Palliative care | 80 | 94.33 (89.81–98.84) | ||
| FACT Fatigue score | ||||
| Standard care | 77 | 23.71 (21.11–26.31) | 3.88 (0.21 to 7.54) | .04 |
| Palliative care | 79 | 27.59 (25.01–30.16) | ||
| ESAS symptom burden score | ||||
| Standard care | 77 | 37.74 (34.09–41.40) | −6.26 (−11.46 to −1.05) | .02 |
| Palliative care | 75 | 31.49 (27.79–35.19) | ||
| HADS Depression subscale score | ||||
| Standard care | 77 | 8.49 (7.59–9.39) | −1.74 (−3.01 to −0.47) | .008 |
| Palliative care | 80 | 6.74 (5.86–7.63) | ||
| HADS Anxiety subscale score | ||||
| Standard care | 77 | 6.33 (5.64–7.02) | −2.26 (−3.22 to −1.29) | <.001 |
| Palliative care | 80 | 4.08 (3.40–4.75) | ||
| PHQ-9 depression symptom score | ||||
| Standard care | 77 | 9.52 (8.42–10.63) | −1.28 (−2.82 to 0.27) | .10 |
| Palliative care | 80 | 8.25 (7.16–9.33) | ||
| At 3 months | ||||
| FACT-BMT score | ||||
| Standard care | 74 | 106.66 (102.91–110.41) | 5.34 (0.04 to 10.65) | .048 |
| Palliative care | 75 | 112.00 (108.28–115.73) | ||
| FACT Fatigue score | ||||
| Standard care | 74 | 35.60 (33.43–37.77) | 2.00 (−1.08 to 5.09) | .20 |
| Palliative care | 73 | 37.60 (35.42–39.79) | ||
| ESAS symptom burden score | ||||
| Standard care | 71 | 17.06 (14.40–19.73) | −2.44 (−6.29 to 1.41) | .21 |
| Palliative care | 69 | 14.62 (11.84–17.40) | ||
| HADS Depression subscale score | ||||
| Standard care | 74 | 5.19 (4.45–5.93) | −1.70 (−2.75 to −0.65) | .002 |
| Palliative care | 74 | 3.49 (2.75–4.23) | ||
| HADS Anxiety subscale score | ||||
| Standard care | 74 | 4.84 (4.15–5.53) | −0.76 (−1.73 to 0.23) | .13 |
| Palliative care | 74 | 4.08 (3.39–4.78) | ||
| PHQ-9 depression symptom score | ||||
| Standard care | 74 | 5.94 (5.02–6.86) | −2.12 (−3.42 to −0.814) | .002 |
| Palliative care | 75 | 3.82 (2.91–4.74) | ||
| PTSD Checklist score | ||||
| Standard care | 67 | 25.79 (23.79–27.79) | −4.35 (−7.12 to −1.58) | .002 |
| Palliative care | 72 | 21.44 (19.53–23.35) | ||
Abbreviations: ESAS, Edmonton Symptom Assessment Scale; FACT-BMT, Functional Assessment of Cancer Therapy–Bone Marrow Transplant; FACT Fatigue, Functional Assessment of Cancer Therapy Fatigue subscale; HADS, Hospital Anxiety and Depression Scale; PHQ-9, Patient Health Questionnaire 9; PTSD, posttraumatic stress disorder.
a
Analysis of covariance adjusting for baseline scores.