Table 7.

Of the 2004–2013 cohort, univariate and multivariate analyses of factors associated with overall survival in pediatric patients.

Parameter	N	Univariate		Multivariate
		HR (95% CI)	p Value	HR (95% CI)	p Value
Gender: male vs. female	240/166	0.990 (0.495–1.981)	0.977
Race: non-white vs. white	59/347	2.061 (0.897–4.733)	0.088
Stage: metastatic vs. non-metastatic	106/279	7.932 (4.416–14.25)	<0.001	4.066 (3.094–5.343)	<0.001
Primary tumor site: axial bones vs. extremity bones	162/132	2.172 (1.194–3.950)	0.011	1.234 (0.878–1.733)	0.226
Primary tumor site: soft tissue vs. extremity bones	91/132	2.137 (0.952–4.798)	0.066	1.767 (1.236–2.525)	0.002
Primary tumor site: other vs. extremity bones	20/132	5.715 (1.161–28.14)	0.032	2.200 (1.456–3.326)	<0.001
Histology: PNET vs. Ewing	45/361	1.416 (0.553–3.629)	0.469
Radiotherapy: yes vs. no	191/213	1.181 (0.589–2.368)	0.639	0.771 (0.601–0.989)	0.040
Cancer surgery: yes vs. no	265/136	0.409 (0.216–0.773)	0.006	0.474 (0.366–0.615)	<0.001
Radiotherapy after surgery vs. prior to surgery	94/9	1.298 (0.300–5.624)	0.727

HR, hazard ratio; CI, confidence interval; PNET, primitive neuroectodermal tumor.

Bold means statistically significant (p < 0.05).