Table 4.

Univariate and multivariate logistic regression for seroconversion in naïve subjects (seronegative at visit 1) with more than one visit (n = 1002).

Seroconverted subjects (n = 122/1002)		Univariate analysis			Multivariate analysisa
Characteristics	n (%)	OR	95% CI	p-Value	aOR	(95% CI)	p-Value
Sex
Male	47 (38.52)	0.84	(0.57–1.24)	0.379	1.31	(1.02–1.68)	0.036
Ethnicity
White (Hispanic)	3 (2.46)	Ref.	–	–	Ref	–	–
Mestizo	113 (92.62)	1.04	(0.31–3.52)	0.950	1.06	(0.52–2.18)	0.866
African descendent	6 (4.92)	1.92	(0.43–8.58)	0.395	3.01	(1.22–7.42)	0.017
Age groups, years (mean 21.8, SD 16.2)
1–5	14 (11.48)	Ref.	–	–	Ref.	–	–
6–10	21 (17.21)	1.3	(0.65–2.66)	0.445	1.43	(0.95–2.14)	0.087
11–15	24 (19.67)	1.66	(0.84–3.31)	0.148	1.67	(1.12–2.48)	0.011
16–20	10 (8.20)	1.76	(0.75–4.13)	0.195	1.60	(0.94–2.72)	0.085
21–30	18 (14.75)	3.09	(1.46–6.5)	0.003	4.17	(2.66–6.54)	<0.001
31–40	14 (11.48)	4.68	(2.08–10.57)	<0.001	4.73	(2.9–7.72)	<0.001
41–50	10 (8.20)	4.57	(1.86–11.22)	0.001	5.68	(3.33–9.7)	<0.001
51–60	10 (8.20)	4.29	(1.75–10.47)	0.001	5.36	(3.11–9.24)	<0.001
>60	1 (0.82)	1.37	(0.16–11.49)	0.771	1.69	(0.55–5.15)	0.357
Neighborhood
La Isla	11 (9.02)	Ref.	–	–	Ref.	–	–
Villa Socorro	12 (9.84)	0.48	(0.20–1.16)	0.105	0.45	(0.27–0.76)	0.003
El Playon	6 (4.92)	0.34	(0.12–0.98)	0.046	0.32	(0.17–0.6)	<0.001
Villa Niza	7 (5.74)	0.46	(0.17–1.28)	0.138	0.39	(0.21–0.73)	0.003
Pablo VI	6 (4.92)	0.32	(0.11–0.93)	0.036	0.35	(0.19–0.65)	0.001
Moscu 1	16 (13.11)	1.0	(0.43–2.34)	0.995	1.02	(0.61–1.7)	0.95
La Frontera	14 (11.48)	1.05	(0.44–2.53)	0.908	1.45	(0.87–2.42)	0.152
Santa Cruz	13 (10.66)	0.56	(0.23–1.35)	0.195	0.47	(0.28–0.81)	0.007
La Francia	6 (4.92)	0.42	(0.15–1.22)	0.112	0.46	(0.24–0.88)	0.019
La Rosa	8 (6.56)	0.45	(0.17–1.19)	0.108	0.53	(0.29–0.94)	0.031
Andalucía	5 (4.10)	0.31	(0.10–0.95)	0.041	0.34	(0.18–0.65)	0.001
Sinai	18 (14.75)	1.31	(0.56–3.03)	0.53	1.24	(0.74–2.08)	0.411
Pre-existing conditionb
Yes	24 (19.67)	1.33	(0.82–2.15)	0.249	1.16	(0.86–1.55)	0.328
Previous DENVc
Yes	4 (3.28)	4.94	(1.37–17.75)	0.014	4.12	(1.88–9.0)	<0.001
Yellow fever vaccinationd
No	27 (22.13)	Ref.	–	–	Ref.	–	–
Yes	53 (43.44)	1.08	(0.66–1.77)	0.749	1.41	(1.06–1.86)	0.017
Don’t know	42 (34.43)	1.82	(1.08–3.06)	0.023	1.78	(1.32–2.42)	<0.001
Fevere	12 (9.84)	0.97	(0.51–1.83)	0.924	1.18	(0.83–1.67)	0.367
Sought caref	6 (4.92)	1.42	(0.58–3.47)	0.446	1.56	(0.94–2.6)	0.084
Symptomsg	111 (90.98)	1.44	(0.75–2.76)	0.271	1.85	(1.16–2.94)	0.009

OR, odds ratio; CI, confidence interval; aOR, adjusted odds ratio.

^aMultivariate logistic regression adjusted by visit, using a fixed-effects model, indicating the aOR of seroconversion on each covariate.

^bSelf-reported comorbidities or previous conditions such as diabetes, hypertension, hypercholesterolemia, etc.

^cSelf-reported previous dengue infection.

^dSelf-reported yellow fever immunization status.

^eSelf-reported presence of fever during the 6 months prior to the visit.

^fSelf-reported medical consultation due to the febrile episode.

^gSelf reported constitutional symptoms/ dengue-like symptoms (headache, myalgia, arthralgia, etc.)