Table 1.

HCV proteins’ effects on insulin sensitivity

NS5A	Core protein
overexpression of PP2A NF-κB-mediated ↑ IL-6 NF-κB-mediated ↑ TNF-α ↑ ROS ↑ IL-18 ↑ SOCS-3	↑ degradation of IRS-1 ↓ PPARγ ↓ PPARα ↑ SOCS-7 activation of mTOR activation of PA28γ activation of JNK