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Evaluation of SEAP expression in KO mice models. TLR7rsq1 (A), MAVS KO (B), and IFNAR KO (C) or WT mice were immunized with VRP or LNP/RNA, and SEAP expression was measured at days 1, 3, and 7. SEAP expression was similarly evaluated after 24-h pretreatment of WT mice with MAR1-5A3 Ab (D). Each dot represents the mean with SEM from five animals. The dotted line represents the average alkaline phosphatase background from the PBS group.
