Nutrient-genome interactions. Nutritional genomics encompasses both nutrigenetics, the influence of genetic variation on nutrient utilization/metabolism, food tolerances, and nutrient requirements; and nutrigenomics, the modulatory role of nutrients on genome evolution, mutation rate, in-utero viability, programming, and expression. In turn, several of the nutrigenomic outcomes (ie, genome evolution) contribute to the genetic variation observed within genetically diverse human populations. NOTE: This figure is available online at www.adajournal.org as part of a PowerPoint presentation.