Table 3.
Neuraminidase inhibitors during pregnancy and risks of neonatal morbidity by affected organ system in Scandinavian countries
| Neonatal morbidity by organ system* | No (%) | Odds ratio (95% CI) | |||
|---|---|---|---|---|---|
| Exposed (n=5502) | Unexposed (n=672 784) | Unadjusted | Adjusted† | ||
| Fetus and newborn affected by maternal factors and by complications of pregnancy, labour, and delivery | 117 (2.1) | 10 940 (1.6) | 1.32 (1.09 to 1.58) | 0.94 (0.77 to 1.14) | |
| Disorders related to length of gestation and fetal growth | 293 (5.3) | 35 632 (5.3) | 1.01 (0.89 to 1.13) | 0.89 (0.79 to 1.01) | |
| Birth trauma | 30 (0.5) | 3248 (0.5) | 1.13 (0.79 to 1.62) | 0.85 (0.58 to 1.24) | |
| Respiratory and cardiovascular disorders specific to perinatal period | 314 (5.7) | 34 630 (5.1) | 1.12 (1.00 to 1.25) | 0.84 (0.75 to 0.95) | |
| Infections specific to perinatal period | 68 (1.2) | 8970 (1.3) | 0.93 (0.73 to 1.18) | 0.78 (0.60 to 1.00) | |
| Haemorrhagic and haematological disorders of fetus and newborn | 186 (3.4) | 24 450 (3.6) | 0.93 (0.80 to 1.07) | 0.89 (0.77 to 1.04) | |
| Transitory endocrine and metabolic disorders specific to fetus and newborn | 114 (2.1) | 13 541 (2.0) | 1.03 (0.86 to 1.24) | 0.84 (0.70 to 1.02) | |
| Digestive system disorders of fetus and newborn | 3 (0.1) | 505 (0.1) | 0.73 (0.23 to 2.27) | 0.87 (0.28 to 2.74) | |
| Conditions involving integument and temperature regulation of fetus and newborn | 27 (0.5) | 1961 (0.3) | 1.69 (1.15 to 2.47) | 1.07 (0.71 to 1.63) | |
| Other disorders originating in perinatal period | 222 (4.0) | 19 753 (2.9) | 1.39 (1.22 to 1.59) | 0.98 (0.86 to 1.13) | |
| All | 912 (16.6) | 96 773 (14.4) | 1.18 (1.10 to 1.27) | 0.92 (0.86 to 1.00) | |
*Numbers are given by diagnosis. ICD-10 codes (P00-P99) for morbidity per organ system are shown in supplementary table B.
†Adjusted for country, year of birth, maternal age, maternal comorbidity, and smoking.