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. 2017 Feb 10;2:9. [Version 1] doi: 10.12688/wellcomeopenres.10646.1

Figure 1. Olfactory receptor (OR) genes are expressed in cancer cell lines.

Figure 1.

A) Histogram representing the frequency (Y axis) of genes expressed per bin of gene expression (X axis: RMA normalised log2-transformed microarray expression data) for a representative melanoma cell line (SK-MEL-5 cell line, COSMIC ID 905956). The green bars represent the OR genes, the white bars all the other genes. The green and the red lines represent the modelling of the 2 peaks of the bimodal distribution. The dashed blue line shows the threshold of expression above which genes have the probability >95% to belong to the distribution of the expressed genes (right distribution in red). B– E Histograms represent the expression of OR gene in 4 representative melanoma cell lines (LB373-MEL-D, LB2518-MEL, SK-MEL-5, GAK with COSMIC IDs 753581, 753579, 905956, 910932, respectively), values displayed as in A. B– C do not show relevant expression of any OR gene, D– E display significant expression of OR2C3 that is an outlier over the other ORs. The red arrow highlights OR2C3 expression level.