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. 2017 May 10;26(14):748–762. doi: 10.1089/ars.2015.6571

FIG. 4.

FIG. 4.

DMF increases FHC in livers and kidneys of sickle mice. (A, B) NY1DD (n = 4/group) and (C, D) HbSS-Townes (n = 3/group) sickle mice with implanted DSFCs were administered DMF (30 mg/kg) or vehicle for 3 or 7 days, respectively. The mice were sacrificed, and the livers and kidneys were removed and frozen 4 h after the infusion of heme and the measurement of stasis. Liver and kidney microsomes were isolated, run on Western blots, and immunostained for FHC (21 kDa) and GAPDH (36 kDa). FHC, ferritin heavy chain.