Table 2.
QT/QTc interval categorical analysisa
Number of subjects (%) | |||||
---|---|---|---|---|---|
QTcF (ms) | Baseline (Day –1) n = 64 | Placebo n = 63 | Vonoprazan 40 mg n = 63 | Vonoprazan 120 mg n = 64 | Moxifloxacin 400 mg n = 64 |
>450 ms | 0 | 0 | 0 | 0 | 1 (1.56) |
>480 ms | 0 | 0 | 0 | 0 | 0 |
>500 ms | 0 | 0 | 0 | 0 | 0 |
>30 ms increase from Baseline | – | 0 | 0 | 0 | 4 (6.25) |
>60 ms increase from Baseline | – | 0 | 0 | 0 | 0 |
>30 ms increase from Baseline and | – | 0 | 0 | 0 | 0 |
>450 ms |
QTcF, QT interval corrected by Fridericia formula.
aResults of QTcB, QTcI, and QTcss (Supplementary Material) were consistent with that of QTcF.