Table 3.
Pharmacokinetic properties
| Pharmacokinetic parameter | Vonoprazan 40 mg (n = 63) | Vonoprazan 120 mg (n = 64) | Moxifloxacin 400 mg (n = 64) |
|---|---|---|---|
| AUC0‐tlqc a (hr·ng/mL) | 490 (181) | 2,420 (720) | 33,000 (6,670) |
| AUC0‐inf a (hr·ng/mL) | 498 (187) | 2,470 (745) | 35,400 (7,350) |
| Cmax a (ng/mL) | 47.1 (15.8) | 226 (76.5) | 2,350 (560) |
| Tmax b (hr) | 2.00 (1.00, 5.00) | 2.00 (1.00, 6.00) | 2.00 (0.500, 5.00) |
| λza (1/hr) | 0.0910 (0.0130) | 0.0910 (0.0150) | 0.0560 (0.00700) |
| T1/2 a (hr) | 7.80 (1.17) | 7.90 (1.47) | 12.6 (1.69) |
| CL/Fa (L/hr) | 91.9 (34.3) | 53.2 (16.1) | 11.7 (2.19) |
| Vz/Fa (L) | 1,000 (327) | 592 (160) | 213 (48.6) |
λz, terminal elimination rate constant; AUC0‐tlqc, area under the plasma concentration–time curve from time 0 to time of the last quantifiable concentration; AUC0‐inf, area under the plasma concentration–time curve from time 0 to infinity; CL/F, apparent clearance after oral administration; Cmax, maximum observed concentration; T1/2, terminal elimination half‐life, Tmax, time to reach maximum observed concentration; Vz/F, apparent volume of distribution.
aMean and standard deviation values are presented.
bMedian and range (min, max) are presented.