Table 4.

Linear relationship between ddQTc and plasma vonoprazan concentration

	Solution for fixed effects				Estimate of ddQTc at Cmax of vonoprazan
	Intercept		Slope		Vonoprazan 40 mg		Vonoprazan 120 mg
ECG parameter (ms)	Estimate	P‐Value	Estimate	P‐Value	Estimate	90% CIa	Estimate	90% CI
QTcFb	0.814	0.204	–0.0117	0.00160d	0.263	–0.787, 1.31	–1.83	–3.39, –0.263
QTcB	–0.209	0.747	–0.0190	≤.0001e	–1.10	–2.16, –0.0454	–4.49	–6.26, –2.73
QTcI	0.812	0.206	–0.0129	0.00140d	0.204	–0.853, 1.26	–2.11	–3.77, –0.445
QTcss	0.825	0.200	–0.0117	0.00160d	0.274	–0.781, 1.33	–1.82	–3.39, –0.246
QT	2.71	0.0217c	0.00230	0.697	2.82	0.920, 4.72	3.24	0.541, 5.93

CI, confidence interval; C_max, maximum observed concentration; ddQTc, change from baseline, placebo‐corrected QT; ECG, electrocardiogram; QTcB, QT interval corrected by Bazett's formula; QTcF, QT interval corrected by Fridericia formula; QTcI, QT interval corrected by individual; QTcss, QT interval study specific corrected.

^aTwo‐sided 90% CI.

^bddQTcF at a particular concentration = 0.8139 – 0.0117 × concentration.

^cIndicates statistical significance at the 0.05 level.

^dIndicates statistical significance at the 0.01 level.

^eIndicates statistical significance at the 0.001 level.