Table 2.

Associations of CYP3A4*22, CYP3A5*3, and SLCO1B1 521C with changes in cholesterol levels after 40 mg simvastatin daily for 6 weeks

	Overall			Whites			African Americans
	No. of patients	∆ LDL‐C (mg/dL)	∆ TC (mg/dL)	No. of patients	∆ LDL‐C (mg/dL)	∆ TC (mg/dL)	No. of patients	∆ LDL‐C (mg/dL)	∆ TC (mg/dL)
CYP3A4
*1/*1	864	−54 ± 22	−57 ± 24	561	‐56 ± 21	‐59 ± 23	303	−51 ± 24	−53 ± 25
*1/*22	54	−56 ± 23	−60 ± 26	46	‐58 ± 21	‐62 ± 23	8	−44 ± 29	−50 ± 38
P valuea		0.816	0.444		0.489	0.307		0.376	0.742
P valueb		0.898	0.726		0.901	0.783		0.820	0.963
CYP3A5
*1/*1	125	−49 ± 25	‐51 ± 24	6	−56 ± 17	−57 ± 16	119	−48 ± 25	−51 ± 25
*1/*3	216	−53 ± 22	‐55 ± 24	73	−56 ± 20	−58 ± 22	143	−51 ± 24	−53 ± 25
*3/*3	537	−57 ± 21	‐59 ± 23	507	−57 ± 21	−59 ± 23	30	−53 ± 21	−57 ± 25
P valuea		0.464	0.328		0.507	0.414		0.832	0.683
P valueb		0.726	0.669		0.901	0.828		0.972	0.963
SLCO1B1
C/C	14	−44 ± 25	−43 ± 27	14	−44 ± 25	−43 ± 27	0	–	–
C/T	151	−55 ± 19	−58 ± 21	137	−55 ± 19	−57 ± 21	14	−57 ± 20	−60 ± 23
T/T	718	−55 ± 22	−58 ± 24	441	−57 ± 22	−60 ± 24	277	−51 ± 23	−54 ± 25
P valuea		0.103	0.028		0.038	0.008		0.310	0.305
P valueb		0.495	0.204		0.366	0.107		0.783	0.783

∆ LDL‐C, change in low‐density lipoprotein cholesterol; ∆ TC, change in total cholesterol; CYP3A4, the gene encoding cytochrome P450, family 3, subfamily A, polypeptide 4; CYP3A5, the gene encoding cytochrome P450, family 3, subfamily A, polypeptide 5; SLCO1B1, the gene encoding solute carrier organic anion transporter family member 1B1.

^aAdjusted for age, smoking status, genetic ancestry (first three multidimensional scaling components) and self‐reported race (when applicable). ^bCorrected for multiple comparisons with a false discovery rate of 5%. Values are presented as mean ± SD. Only P values <0.05 are bolded.