Fig. 2.

Loss of Bu-1+ B-cells within the BF of IBDV susceptible RIR birds after IBDV infection (48hpi) is associated with increased genomic 5hmC levels. Comparative levels of the B cell marker, Bu-1 (green) and 5hmC (red) within sectioned BF of mock (A, E, I) and infected (B, F, J) resistant 15l or mock (C, G, K) and infected (D, H, L) susceptible RIR as measured by immunofloresence. Individual bursal follicles are delineated within white dashed lines. White chevrons indicate yellow staining that suggests B cells expressing both Bu-1 and increased 5hmC levels.