Table 2. Phenotypic characteristics of normotensive (N) or hypertensive (H) LDLR KO mice fed either a normal-sodium (NS) or a low-sodium (LS) diet and treated or not with losartan (Los) or hydralazine (Hyd).

	N-NS (n = 7)	H-NS (n = 8)	N-LS (n = 8)	H-LS (n = 8)	H-LS + Los (n = 7)	H-LS + Hyd (n = 8)
Body weight (g)	24.5 ± 0.6	24.7 ± 1.7	22.6 ± 0.9	22.8 ± 2.5	21.2 ± 2.5	24 ± 0.5
Hematocrit (fraction)	0.51 ± 0.2	0.52 ± 0.3	0.53 ± 0.4	0.53 ± 0.2	0.45 ± 0.4 c	0.48 ± 0.3
BP (mmHg)	76 ± 3	131 ± 4	67 ± 7 a	107 ± 3 b, c	59 ± 4	65 ± 6
UNa (mEq/24 h)	0.043 ± 0.015	0.077 ± 0.047	0.024 ± 0.008 a	0.027 ± 0.018 b	0.027 ± 0.008	0.020 ± 0.009
TC (mmol/L)	13.1 ± 0.8	14.1 ± 1.5	16.6 ± 2.8 a	18.6 ± 4.9 b	19.7 ± 2.6	15.1 ± 2.77
TG (mmol/L)	1.86± 0.17	1.42 ± 0.81	2.99 ± 0.75 a	2.53 ± 0.38 b	1.64 ± 1.05 c	2.72 ± 0.82
NEFA (mmol/L)	1.97 ± 0.17	1.38 ± 0.27	1.64 ± 0.77	1.74 ± 0.47	1.01 ± 0.26 c	1.84 ± 0.52

Number of animals (n); mean ± SD.

^a P < 0.05 N-NS vs N-LS, unpaired Student's t test

^b P < 0.05 H-NS vs H-LS

unpaired Student's t test

^c P < 0.05 comparing all LS groups, ANOVA with Newman Keuls post hoc test.