Table 2. Profile of patients with grade 4–5 toxicity.
| Patient #1 | Patient #2 | Patient #3 | Patient #4 | Patient #5 | |
|---|---|---|---|---|---|
| Toxicity* | Toxic death** (cycle 1) | G4 anemia G4 thrombopenia G3 neutropenia (cycle 1) |
G4 thrombopenia G3 asthenia (cycle 1) |
G3 neurotoxicity (cycle 1) G4 thrombopenia G4 neutropenia G4 leucopenia (cycle 2) |
G4 diarrhea (cycle 2) |
|
Mean capecitabine dose intensity at cycle 1 (mg/m2/day) |
1530 | 2030 | 1790 | 2490 | 2170 |
| PS at inclusion | 0 | 1 | na | 2 | 0 |
|
Pre-treatment UH2/U Pre-treatment U (ng/ml) |
6.5 16.7 |
14.0 12.9 |
13.5 22.0 |
na na |
na na |
|
DPYD variants |
|||||
| c.-477T>G | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| C29R | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| F100L | wt/wt | wt/wt | wt/wt | VAR/wt | wt/wt |
| c.483+837A>G § | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| c.483+1342T>A § | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| c.483+1344T>A § | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| M166V § | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| c.1129-15T>C § | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| S492L | wt/wt | wt/wt | wt/wt | wt/wt | VAR/wt |
| D949V | VAR/wt | wt/wt | wt/wt | wt/wt | wt/wt |
| c.*274T>C §§ | wt/wt | VAR/VAR | wt/wt | wt/wt | wt/wt |
| c.*432T>A | wt/wt | wt/wt | VAR/wt | wt/wt | wt/wt |
| c.*768G>A §§ | VAR/VAR | wt/wt | VAR/VAR | VAR/VAR | wt/wt |
| c.*780C>T §§ | VAR/wt | wt/wt | VAR/VAR | VAR/wt | wt/wt |