Table 3. Association results of SNPs in CDKN2A/B and B-hyperdiploid ALL and ETV6-RUNX1 ALL.
| B-hyperdiploid ALL | ETV6-RUNX1 ALL | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Genotype | N (controls) | N (cases) | OR (CI 95%) | P | N (cases) | OR (CI 95%) | P |
| SNP | (N = 330) | (N = 54) | (N = 37) | |||||
| ANRIL | AA | 264 (80.2) | 40 (74.1) | Recessive | 0.007a | 22 (62.9) | Dominant | 0.024 |
| rs2811712 | AG | 62 (18.8) | 10 (18.5) | 8.69 (1.89–40.0) | (0.048) | 12 (34.3) | 2.4 (1.15–5.02) | |
| GG | 3 (0.9) | 4 (7.4) | 1 (2.9) | |||||
| A | 590 (91.2) | 90 (90.7) | 1.73 (0.98–3.05) | 0.055 | 56 (80) | 2.16 (1.14–4.1) | 0.017 | |
| G | 68 (8.8) | 18 (9.3) | 14 (20) | |||||
| CDKN2A | CC | 217 (92.7) | 39 (83) | Dominant | 0.048 | 28 (90.3) | Dominant | 0.64 |
| rs3731249 | CT | 16 (6.8) | 8 (17) | 2.62 (1.06–6.48) | 3 (9.7) | 1.37 (0.38–4.96) | ||
| TT | 1 (0.4) | 0 | 0 | |||||
| C | 450 (96.2) | 86 (91.5) | 2.32 (0.98–5.51) | 0.55 | 59 (95.2) | 1.27 (0.36–4.44) | 0.70 | |
| T | 18 (3.8) | 8 (8.5) | 3 (4.8) | |||||
| CDKN2A | GG | 203 (79.6) | 38 (70.4) | Additive | 0.06 | 23 (67.6) | Dominant | 0.12 |
| rs2811709 | AG | 49 (19.2) | 13 (24.1) | 1.72 (0.98–3.01) | 11 (32.4) | 1.87 (0.86–4.07) | ||
| AA | 3 (1.2) | 3 (5.6) | 0 | |||||
| G | 455 (89.2) | 89 (82.4) | 1.76 (0.99–3.11) | 0.05 | 57 (83.8) | 1.59 (0.79–3.22) | 0.19 | |
| A | 55 (10.8) | 19 (17.6) | 11 (16.2) | |||||
| CDKN2B, ANRIL | TT | 125 (38.1) | 23 (42.6) | Dominant | 0.53 | 12 (34.3) | Dominant | 0.65 |
| rs1063192 | CT | 162 (49.4) | 24 (44.4) | 0.83 (0.46–1.49) | 17 (48.6) | 1.18 (0.57–2.46) | ||
| CC | 41 (12.5) | 7 (13) | 6 (17.1) | |||||
| T | 412 (62.8) | 70 (64.8) | 0.91 (0.59–1.4) | 0.68 | 41 (58.8) | 1.19 (0.72–1.97) | 0.48 | |
| C | 244 (37.2) | 38 (35.2) | 29 (41.4) | |||||
| CDKN2A | AA | 246 (74.8) | 41 (77.4) | Dominant | 0.68 | 27 (77.1) | Dominant | 0.75 |
| rs3731222 | AG | 78 (23.7) | 12 (22.6) | 0.87 (0.44–1.73) | 7 (20) | 0.88 (0.38–2.01) | ||
| GG | 5 (1.5) | 0 | 1 (2.9) | |||||
| A | 570 (86.6) | 94 (88.7) | 0.82 (0.43–1.57) | 0.56 | 61 (87.1) | 0.95 (0.45–1.99) | 0.90 | |
| G | 88 (13.4) | 12 (11.3) | 9 (12.9) | |||||
| CDKN2B, ANRIL | GG | 95 (28.9) | 17 (31.5) | Recessive | 0.93 | 15 (44.1) | Aditive | 0.030 |
| rs3217992 | AG | 153 (46.5) | 24 (44.4) | 0.97 (0.5–1.9) | 15 (44.1) | 0.58 (0.34–0.96) | ||
| AA | 81 (24.6) | 13 (24.1) | 4 (11.8) | |||||
| G | 343 (52.1) | 58 (53.7) | 0.93 (0.62–1.41) | 0.76 | 45 (66.2) | 0.55 (0.32–0.94) | 0.028 | |
| A | 315 (47.9) | 50 (46.3) | 23 (33.8) | |||||
Abbreviations: CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism
a Significant after FDR correction, the p value is displayed in brackets