Table 3. Gene-gene interaction models identified by the GMDR method with adjustment for age, gender, and education.
| Interaction model | Testing accuracy (%) | P value |
|---|---|---|
| CASS4 rs911159, EPHA1 rs10952552 | 52.56 | 0.259 |
| CASS4 rs911159, FERMT2 rs4901317 | 53.57 | 0.139 |
| CASS4 rs911159, MEF2C rs9293506 | 52.52 | 0.262 |
| CASS4 rs911159, PLD3 rs11672825 | 55.85 | 0.059 |
| CASS4 rs911159, RIN3 rs1885747 | 48.31 | 0.699 |
| CASS4 rs911159, SLC24A4 rs67063100 | 56.53 | 0.035 |
| EPHA1 rs10952552, FERMT2 rs4901317 | 46.39 | 0.840 |
| EPHA1 rs10952552, MEF2C rs9293506 | 55.12 | 0.093 |
| EPHA1 rs10952552, PLD3 rs11672825 | 51.36 | 0.361 |
| EPHA1 rs10952552, RIN3 rs1885747 | 49.35 | 0.626 |
| EPHA1 rs10952552, SLC24A4 rs67063100 | 57.69 | 0.016 |
| FERMT2 rs4901317, MEF2C rs9293506 | 57.47 | 0.008 |
| FERMT2 rs4901317, PLD3 rs11672825 | 49.84 | 0.519 |
| FERMT2 rs4901317, RIN3 rs1885747 | 48.37 | 0.691 |
| FERMT2 rs4901317, SLC24A4 rs67063100 | 58.48 | 0.004 |
| MEF2C rs9293506, PLD3 rs11672825 | 55.02 | 0.104 |
| MEF2C rs9293506, RIN3 rs1885747 | 49.65 | 0.570 |
| MEF2C rs9293506, SLC24A4 rs67063100 | 58.05 | 0.009 |
| PLD3 rs11672825, RIN3 rs1885747 | 48.96 | 0.600 |
| PLD3 rs11672825, SLC24A4 rs67063100 | 54.65 | 0.142 |
| RIN3 rs1885747, SLC24A4 rs67063100 | 55.34 | 0.085 |
GMDR = generalized multifactor dimensionality reduction.
P value was based on 1,000 permutations. Analysis was obtained after adjustment for covariates including age, gender, and education. P values of < 0.05 are shown in bold.