Table 4. Gene-lifestyle interaction models identified by the GMDR method with adjustment for age, gender, and education.
| Interaction model | Testing accuracy (%) | P value |
|---|---|---|
| CASS4 rs911159, smoking | 50.85 | 0.416 |
| CASS4 rs911159, alcohol consumption | 52.15 | 0.287 |
| CASS4 rs911159, physical activity | 50.03 | 0.520 |
| CASS4 rs911159, social support | 52.68 | 0.233 |
| EPHA1 rs10952552, smoking | 52.40 | 0.275 |
| EPHA1 rs10952552, alcohol consumption | 52.74 | 0.247 |
| EPHA1 rs10952552, physical activity | 47.16 | 0.766 |
| EPHA1 rs10952552, social support | 53.76 | 0.156 |
| FERMT2 rs4901317, smoking | 50.75 | 0.388 |
| FERMT2 rs4901317, alcohol consumption | 50.25 | 0.461 |
| FERMT2 rs4901317, physical activity | 45.70 | 0.862 |
| FERMT2 rs4901317, social support | 50.99 | 0.388 |
| MEF2C rs9293506, smoking | 54.39 | 0.081 |
| MEF2C rs9293506, alcohol consumption | 53.75 | 0.147 |
| MEF2C rs9293506, physical activity | 52.53 | 0.282 |
| MEF2C rs9293506, social support | 55.65 | 0.039 |
| PLD3 rs11672825, smoking | 47.86 | 0.690 |
| PLD3 rs11672825, alcohol consumption | 50.39 | 0.449 |
| PLD3 rs11672825, physical activity | 49.04 | 0.598 |
| PLD3 rs11672825, social support | 49.87 | 0.535 |
| RIN3 rs1885747, smoking | 45.49 | 0.899 |
| RIN3 rs1885747, alcohol consumption | 46.39 | 0.838 |
| RIN3 rs1885747, physical activity | 46.13 | 0.857 |
| RIN3 rs1885747, social support | 47.95 | 0.723 |
| SLC24A4 rs67063100, smoking | 55.86 | 0.041 |
| SLC24A4 rs67063100, alcohol consumption | 57.64 | 0.008 |
| SLC24A4 rs67063100, physical activity | 56.81 | 0.038 |
| SLC24A4 rs67063100, social support | 54.25 | 0.126 |
GMDR = generalized multifactor dimensionality reduction.
P value was based on 1,000 permutations. Analysis was obtained after adjustment for covariates including age, gender, and education. P values of < 0.05 are shown in bold.