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. 2017 Feb 25;8(15):24099–24109. doi: 10.18632/oncotarget.15732

Figure 5. Exogenous Ang II triggers apoptosis of dopaminergic neurons via an AT1R-dependent manner in the right SN of rats.

Figure 5

The right SN of rats were infused with vehicle, Ang II (60 ng/h), Ang II (60 ng/h) + losartan (200 ng/h) or losartan (200 ng/h) for one-week. A. TH-immunoreactive neurons in the right SN of each group. Scale bar: 500 μm. B. Quantitative analysis of TH-positive neurons in the right SN of each group. C. The activity of caspase-3 in the right SN of each group was measured by a colorimetric assay kit. n = 6 per group. Data were analyzed by one-way ANOVA followed by Tukey's post hoc test. Columns represent mean±SD. *P < 0.05 vs. control group, #P < 0.05 vs. Ang II group.