Table 3. Comparison of overall marker intensities between negative vs PDAC specimens.
| Covariate | Signal Intensity, CU/ug (Mean ± SD, median) | P value | |
|---|---|---|---|
| Negative (N=10) | PDAC (N=70) | ||
| Total Cytokeratin (CK) | 116.76 ± 167.12, 47.15 | 536.93 ± 733.89, 354.25 | 0.002 |
| Phospho-HER1 | 4.17 ± 5.76, 1.89 | 1.95 ± 2.65, 1.03 | 0.234 |
| Phospho-HER2 | 0.33 ± 0.35, 0.14 | 2.78 ± 4.2, 1.15 | 0.007 |
| Phospho-HER3 | 14.12 ± 14.84, 7.65 | 38.36 ± 45.71, 22.98 | 0.026 |
| Phospho-c-MET | 0.15 ± 0.16, 0.05 | 0.76 ± 1.46, 0.26 | 0.051 |
| Phospho-IGFR | 37.30 ± 47.26, 29.16 | 25.61 ± 45.06, 12.06 | 0.363 |
| Phospho-PI3K | 46.37 ± 44.40, 25.17 | 33.49 ± 32.5, 28.93 | 0.399 |
| Phospho-SHC | 3.23 ± 4.14, 1.84 | 5.56 ± 5.62, 4.21 | 0.200 |
| Total HER1 | 54.38 ± 47.42, 42 | 61.44 ± 62.16, 40.25 | 0.765 |
| Total HER2 | 1.22 ± 1.26, 0.55 | 10.18 ± 14.46, 3.9 | 0.006 |
| Total HER3 | 54.72 ± 66.72, 25.0 | 387.96 ± 722.64, 120.2 | 0.008 |
| Total c-MET | 72.65 ± 66.73, 60.0 | 441.29 ± 649.53, 288.05 | <0.001 |
| Total IGFR | 23.82 ± 15.67, 15.0 | 83.69 ± 108.82, 43.34 | 0.012 |
| Phospho-AKT | 0.80 ± 1.23, 0.26 | 3.25 ± 5.47, 1.36 | 0.046 |
| Phospho-ERK1/2 | 0.92 ± 0.86, 0.88 | 7.8 ± 10.66, 4.78 | <0.001 |
| Phospho-MEK | 0.36 ± 0.21, 0.43 | 1.77 ± 2.54, 0.74 | 0.120 |
| Phospho-RSK | 24.06 ± 17.89, 14.94 | 80.26 ± 80.7, 48.02 | 0.127 |
| Phospho-PRAS40 | 12.61 ± 28.33, 1.0 | 41.6 ± 68.5, 9.24 | 0.043 |
| Phospho-RPS6 | 50.13 ± 87.00, 4.84 | 18.74 ± 60.08, 1.58 | 0.377 |