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. 2017 Feb 21;8(15):24564–24578. doi: 10.18632/oncotarget.15596

Table 3. The pathways and GO processes most strongly enriched by targets of validated microRNAs.

Function enrichment FDR Targets
GO processes
GO:0006355: regulation of transcription, DNA-dependent 1.44E-99 584
GO:0007165: signal transduction 3.90E-65 415
GO:0045944: positive regulation of transcription from RNA polymerase II promoter 1.73E-60 255
GO:0007275: multicellular organismal development 2.49E-57 344
GO:0045893: positive regulation of transcription, DNA-dependent 4.03E-53 213
GO:0045892: negative regulation of transcription, DNA-dependent 7.61E-50 189
GO:0000122: negative regulation of transcription from RNA polymerase II promoter 2.83E-46 188
GO:0007411: axon guidance 3.19E-46 156
GO:0007264: small GTPase mediated signal transduction 1.86E-41 151
GO:0007399: nervous system development 1.95E-41 179
KEGG pathways
Kegg:05200: Pathways in cancer 6.81E-32 140
Kegg:04510: Focal adhesion 7.54E-30 100
Kegg:04010: MAPK signaling pathway 6.53E-30 119
Kegg:04360: Axon guidance 9.56E-30 77
Kegg:04810: Regulation of actin cytoskeleton 7.85E-27 99
Kegg:04722: Neurotrophin signaling pathway 5.66E-24 69
Kegg:04144: Endocytosis 3.31E-23 89
Kegg:04520: Adherens junction 5.84E-22 48
Kegg:04141: Protein processing in endoplasmic reticulum 1.07E-19 74
Kegg:04910: Insulin signaling pathway 9.19E-19 65
Panther Pathways
Panther:P00018: EGF receptor signaling pathway 3.82E-21 63
Panther:P00034: Integrin signalling pathway 1.99E-20 75
Panther:P00047: PDGF signaling pathway 2.15E-17 62
Panther:P00057: Wnt signaling pathway 2.92E-17 102
Panther:P00021: FGF signaling pathway 1.16E-16 55
Panther:P00005: Angiogenesis 3.34E-16 67
Panther:P04393: Ras Pathway 3.89E-14 39
Panther:P00031: Inflammation mediated by chemokine and cytokine signaling pathway 5.79E-13 73
Panther:P00052: TGF-beta signaling pathway 5.03E-12 43
Panther:P00029: Huntington disease 1.34E-11 52