Table 2. Multivariate analysis of overall survival (OS) and disease-specific survival (DSS) predictors using cox proportional hazard model.
| OS | DSS | |||
|---|---|---|---|---|
| HR (95% CI) | P-Valuea | HR (95% CI) | P-Valuea | |
| Age at diagnosis (years) | ||||
| 18–49 | Reference | - | Reference | - |
| 50–79 | 1.663 (1.615–1.713) | < 0.001 | 1.199 (1.160–1.240) | < 0.001 |
| Race | ||||
| White | Reference | - | Reference | - |
| Black | 1.276 (1.233–1.321) | < 0.001 | 1.293 (1.240–1.348) | < 0.001 |
| Othersb | 0.756 (0.719–0.796) | < 0.001 | 0.778 (0.732–0.828) | < 0.001 |
| Unknown | 0.353 (0.257–0.486) | < 0.001 | 0.399 (0.273–0.582) | < 0.001 |
| Marital status | ||||
| Married | Reference | - | Reference | - |
| Not marriedc | 1.460 (1.422–1.499) | < 0.001 | 1.241(1.201–1.282) | < 0.001 |
| Unknown | 1.119 (1.039–1.207) | 0.003 | 1.004 (0.913–1.105) | 0.928 |
| Histology type | ||||
| IDC | Reference | - | Reference | - |
| AAC | 0.834 (0.695–1.002) | 0.052 | 0.800 (0.639–1.001) | 0.051 |
| Grade | ||||
| I | Reference | - | Reference | - |
| II | 1.252 (1.191–1.316) | < 0.001 | 2.257 (2.052–2.483) | < 0.001 |
| III + UDd | 1.671 (1.588–1.758) | < 0.001 | 3.685 (3.351–4.051) | < 0.001 |
| Unknown | 1.161 (1.053–1.280) | 0.003 | 2.266 (1.964–2.615) | < 0.001 |
| Tumor size (cm) | ||||
| ≤ 2 | Reference | - | Reference | - |
| > 2 and ≤ 5 | 1.741 (1.690–1.794) | < 0.001 | 2.190 (2.106–2.278) | < 0.001 |
| > 5 | 2.994 (2.864–3.131) | < 0.001 | 3.891 (3.690–4.103) | < 0.001 |
| Unknown | 4.007 (3.687–4.355) | < 0.001 | 5.578 (5.089–6.114) | < 0.001 |
| LN status | ||||
| Negative | Reference | - | Reference | - |
| Positive | 2.014 (1.958–2.072) | < 0.001 | 2.775 (2.675–2.878) | < 0.001 |
| Unknown | 3.148 (2.967–3.339) | < 0.001 | 3.198 (2.940–3.478) | < 0.001 |
| ER status | ||||
| Negative | Reference | - | Reference | - |
| Positive | 0.743 (0.714–0.772) | < 0.001 | 0.683 (0.652–0.716) | < 0.001 |
| PR status | ||||
| Negative | Reference | - | Reference | - |
| Positive | 0.771 (0.743–0.801) | < 0.001 | 0.641 (0.611–0.672) | < 0.001 |
| Surgery type | ||||
| Mastectomy | Reference | - | Reference | - |
| BCS | 0.832 (0.807–0.857) | < 0.001 | 0.794 (0.765–0.824) | < 0.001 |
| Unknown | 1.088 (0.828–1.428) | 0.546 | 1.517 (1.138–2.022) | 0.005 |
| Radiation | ||||
| No | Reference | - | Reference | - |
| Yes | 0.779 (0.757–0.802) | < 0.001 | 0.872 (0.842–0.903) | < 0.001 |
| Unknown | 0.942 (0.877–1.011) | 0.096 | 1.012 (0.930–1.102) | 0.778 |
AAC = apocrine adenocarcinoma, IDC = infiltrating ductal carcinoma, ER = estrogen receptor, PR = progesterone receptor, HER2 = human epidermal growth factor receptor 2, LN = lymph node, NOS = no other specific, BCS = breast conserving surgery, HR = hazard ratio, CI = confidence interval, DSS = disease-specific survival, OS = overall survival.
aP-value was determined by multivariate Cox proportional hazard regression model.
bIncluding American Indian/Alaskan native, and Asian/Pacific Islander, and others-unspecified.
cIncluding divorced, separated, single (never married), unmarried, domestic partner and widowed.
dIncluding grade 3 and undifferentiated.