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. 2017 Mar 1;8(15):24815–24827. doi: 10.18632/oncotarget.15820

Figure 1. SRGN is overexpressed in human cancers.

Figure 1

High SRGN expression in human glioma correlates with low survival rate. (A) Comparison of SRGN expression patterns across major human cancers: prostate (n = 72), ovary (n = 256), lung (n = 121), kidney (n = 261), endometrium (n = 209), colon (n = 315), breast (n = 351), myeloma (n = 542), hepatocellular carcinoma (HCC) (n = 91), glioblastoma (GBM) (n = 84), non-small cell lung carcinoma (NSCLC) (n = 410), medulloblastoma (MB) (n = 73), B-cell lymphoma (n = 420). All clinical data for this analysis was obtained from the R2 genomic analysis platform. (B) Survival analysis comparing GBM patient survival with high and low SRGN expression. Log-rank p-value = 0.037 (n = 504). Clinical data for the TCGA patients was obtained from the TCGA portal and in each case the maximum value of the survival time available was used. Significant differences in survival between groups were evaluated using a Kaplan-Meier analysis with censoring at confidence interval 95%.