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. 2017 Mar 1;8(15):24815–24827. doi: 10.18632/oncotarget.15820

Figure 6. Serglycin can induce aggressiveness and propagation in glioma cells.

Figure 6

(A) Immunohistochemical staining for ZEB-1 in high-grade human glioma TMAs. Representative high-grade glioma TMA core (upper left panel) and selected magnified area (upper right panel) showing ZEB-1 expression and quantification of the ZEB-1 expression level (lower panel). HGG TMAs included tumor tissue from high-grade gliomas (anaplastic gliomas and glioblastomas, n = 101). Scale bar = 200 μm. (B) ZEB-1 expression levels positively correlates to the serglycin expression levels in high-grade glioma (Pearson correlation ρ < 0.01). (C) Expression analysis for ZEB-1, vimentin and Ki67 in the glioma cells after co-culture with LAD2 cells for 48 hours. All the results are represented as increase in fold expression compared to the expression levels without co-culture. The experiments were performed 3 times, with triplicates in each case. Data is expressed as mean values + SEM and significance differences between GC+MC and GC are indicated in the figure. *p < 0.05, **p < 0.01 versus cells grown without co-culture. LGG = low-grade glioma, HGG = high-grade glioma. GC = glioma cells, GC+MC = glioma cells co-cultured with LAD2 cells.