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. 2017 Feb 15;8(15):24949–24963. doi: 10.18632/oncotarget.15327

Figure 6. Overexpression of miR-29a inhibits the expression of WTAP and activation of the PI3K/AKT/ERK pathways by downregulating QKI-6.

Figure 6

A. Western blot analysis of WTAP expression, as regulated by miR-29a and QKI-6 in GSCs. B. The expression of p-PI3K/PI3K, p-AKT/AKT and p-ERK/ERK in GSCs-U87 with altered expression of miR-29a and QKI-6. C. Western blot analysis of p-PI3K/PI3K, p-AKT/AKT and p-ERK/ERK expression, as regulated by miR-29a and QKI-6 in GSCs-U251. D. Overexpression of miR-29a inhibited the activation of the p-PI3K/PI3K, p-AKT/AKT and p-ERK/ERK pathways by downregulating QKI-6 in GSCs-GTD. GAPDH was used as an internal loading control. Accompanying graphs display the densitometry analysis of protein expression. Values represent the mean ± SD from five independent experiments.*P<0.05 vs. agomir-29a-NC group,#P<0.05 vs. agomir-29a-NC+pGPU6-shQKI-6-NC group, &P<0.05 vs. agomir-29a group. IDVs represent the relative integrated density values.