Table 2. Significantly altered directional connectivity from and to bilateral amygdala and hippocampus in MDD-aMCI and aMCI patients.
| Region | Cluster size | MNI coordinates (mm) | Peak t value | |||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| From Left Amygdala | ||||||
| aMCI vs Cs | SMA (L/R) | 66 | -3 | 9 | 51 | 5.91 |
| From Right Amygdala | ||||||
| MDD-aMCI vs Cs | LG/ CG (R) | 71 | 18 | -72 | -9 | 5.92 |
| aMCI vs Cs | SMA (L/R) | 75 | -3 | 9 | 51 | 5.65 |
| MDD-aMCI vs aMCI | LG/ CG (R) | 60 | 9 | -81 | 0 | 4.41 |
| SMA (L/R) | 86 | -6 | 9 | 51 | -4.50 | |
| To Left Hippocampus | ||||||
| MDD-aMCI vs Cs | SPG (L) | 40 | -18 | -72 | 45 | 5.42 |
| SOG/MOG (L) | 34 | -18 | -72 | 45 | 5.42 | |
| MDD-aMCI vs aMCI | SPG (L) | 43 | -18 | -72 | 45 | 5.82 |
| SOG/MOG (L) | 25 | -18 | -72 | 45 | 5.82 | |
Abbreviations: MDD-aMCI, both with Major Depression Disorder and Amnestic Mild Cognitive Impairment; aMCI, Amnestic Mild Cognitive Impairment; Cs, Controls; L, Left; R, Right; LG = Lingual Gyrus; CG, Calcarine Gyrus; SMA, Supplementary Motor Area; SPG, Superior Parietal Gyrus; SOG/MOG, Superior / Middle Occipital Gyrus.