Table 2. Univariate and multivariate analysis of factors correlated with long-term outcome.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR (95% C.I.) | p value | HR (95% C.I.) | p value | |
| Age | 0.994 (0.971 – 1.018) | 0.629 | - | - |
| Male gender | 3.571 (1.093 – 11.670) | 0.035 | 3.351 (1.013 – 11.089) | 0.048 |
| BMI | 0.995 (0.920 – 1-076) | 0.906 | - | - |
| NYHA | 1.462 (0.960 – 2.227) | 0.076 | - | - |
| NYHA III | 2.343 (1.162 – 4.724) | 0.017 | - | - |
| SPB | 0.995 (0.975 – 1.014) | 0.595 | - | - |
| HR | 1.002 (0.979 – 1.026) | 0.842 | - | - |
| Atrial fibrillation | 2.634 (1.194 – 5.811) | 0.016 | 2.564 (1.143 – 5.752) | 0.022 |
| LBBB | 1.355 80.695 – 2.641) | 0.372 | - | - |
| Hb | 0.962 (0.787 – 1.177) | 0.709 | - | - |
| Anemia | 2.222 (1.083 – 4.557) | 0.029 | - | - |
| Creatinine | 2.007 (1.082 – 3.512) | 0.027 | - | - |
| GFR MDRD | 0.994 (0.978 – 1.010) | 0.464 | - | - |
| GFR ≤ 60 ml/min | 2.206 (1.129 – 4.311) | 0.021 | - | - |
| Sodium | 0.905 (0.812 – 1.009) | 0.072 | 0.893 (0.798 – 0.999) | 0.048 |
| LV EDD index | 1.011 (0.949 – 1.076) | 0.745 | - | - |
| LVEF | 0.968 (0.937 – 0.999) | 0.044 | - | - |
| MR | 1.184 (0.841 – 1.667) | 0.333 | - | - |
| Moderate-severe MR | 1.509 (0.770 – 2.956) | 0.230 | - | - |
| ACE inhibitors/ARB | 2.422 (0.332 – 17.699) | 0.383 | - | - |
| Beta – blockers | 2.389 (0.327 – 17.454) | 0.391 | - | - |
| ICD | 0.949 (0.488 – 1.846) | 0.878 | - | - |
| CRT | 1.449 (0.679 – 3.094) | 0.338 | - | - |
| CRT-D | 1.234 (0.631 – 2.411) | 0.539 | - | - |
| BNP | 1.001 (1.000 – 1.001) | 0.135 | - | - |
| IL – 1β | 1.069 (1.028 – 1.113) | 0.001 | 1.193 (1.056 – 1.349)** | 0.005 |
| IL – 6 | 1.000 (0.998 – 1.002) | 0.991 | - | - |
| IL – 10 | 1.000 (0.998 – 1.001) | 0.650 | - | - |
Abbreviations: ACEI/ARBs: angiotensin converting enzyme inhibitors/angiotensin receptor blockers; BMI: body mass index; BNP: B-type natriuretic peptide; CRT: cardiac resynchronization therapy; CRT-D: cardiac resynchronization therapy defibrillator; EDD: end-diastolic diameter; GFR: glomerular filtration rate; Hb: haemoglobin; ICD: implantable cardioverter defibrillator; IL: interleukin; LBBB: left bundle branch block; LV: left ventricular; LVEF: left ventricular ejection fraction; MDRD: Modification of Diet in Renal Disease; MR: mitral regurgitation;; NYHA: New York Heart Association; SBP: systolic blood pressure.
**log squared transformed values.