Table 1. Patient and treatment characteristics in patients with and without mutation profiling data.
Mutation data (N = 78) | No mutation data (N = 112) | p-value (χ2) | |||
---|---|---|---|---|---|
N | % | N | % | ||
Sex | 0.40 | ||||
Female | 20 | 26 | 35 | 31 | |
Male | 58 | 74 | 77 | 69 | |
Age (years) | 0.27 | ||||
< 60 | 44 | 56 | 54 | 48 | |
≥ 60 | 34 | 44 | 58 | 52 | |
Median[range] | 57.9 [30.7 ; 88.9] | 60.6 [34.4 ; 85.0] | |||
Performance status | 0.08 | ||||
0 | 38 | 49 | 69 | 62 | |
≥ 1 | 40 | 51 | 43 | 38 | |
Histology | 0.10 | ||||
Adenocarcinoma | 40 | 51 | 44 | 39 | |
Other* | 38 | 49 | 68 | 61 | |
T-stage | 0.60 | ||||
T0–T2 | 35 | 45 | 46 | 41 | |
T3–T4 | 43 | 55 | 66 | 59 | |
N-stage | 0.53 | ||||
N0–N1 | 13 | 17 | 15 | 13 | |
N2–N3 | 65 | 83 | 97 | 87 | |
Stage | 0.001 | ||||
IIIA | 47 | 60 | 41 | 37 | |
IIIB | 31 | 40 | 71 | 63 | |
Smoking status | 0.16 | ||||
Current smoker | 31 | 40 | 56 | 50 | |
Never or former smoker | 47 | 60 | 56 | 50 | |
Diabetes | 0.04 | ||||
No | 68 | 87 | 107 | 96 | |
Yes | 10 | 13 | 5 | 4 | |
Radiotherapy dose | 0.78 | ||||
< 66 Gy | 27 | 35 | 41 | 37 | |
≥ 66 Gy | 51 | 65 | 71 | 63 | |
Thoracic surgery | 0.06 | ||||
No | 60 | 77 | 98 | 87 | |
Yes | 18 | 23 | 14 | 13 |
Includes large cell carcinoma, mixed cell carcinoma, neuroendocrine markers, squamous cell carcinoma, undifferentiated tumor.