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. 2017 Mar 9;8(15):25211–25225. doi: 10.18632/oncotarget.16056

Figure 2. SU5416 increases the expression of AhR target genes.

Figure 2

(A–B) SU5416 activates the AhR target gene CYP1A1 in mouse and human hepatoma cells lines, respectively. Data are the mean ± SEM of three or more independent determinations. *p < 0.01, **p < 0.001. (C) Identification of an AhR gene induction signature in vivo form the lungs of rats treated with a single dose of SU5416. Intensity data is shown on a log2 intensity scale. Groups (bottom labels) consists of normoxia exposed rats (null), hypoxia exposed rats (hypx), and hypoxia exposed rats treated with SU5416 (hypx+SU); each column corresponds to an independent animal. (D) SU5416 suppresses AhR protein levels. Hepa1 cells were plated in 6 well plates and treated with SU5416 (20 μM). Cells were collected at the indicated time points, and whole cell lysates were prepared and analyzed by Western blot with the indicated antibodies.