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. 2017 Feb 27;8(15):25270–25278. doi: 10.18632/oncotarget.15751

Table 4. Meta-analysis of BCL-2 promoter polymorphisms and cancer prognosis.

Genetic model No.ofstudies PQ I2 HR 95% CI PZ Model
rs2279115
Total 13(4013/5319)
CC vs. CA 0.011 59.6% 1.09 1.03,1.51 <0.001 Random-effects model
CC vs. AA 0.018 58.5% 1,18 1.07,1.66 <0.001 Random-effects model
CA vs. AA 0.677 0.00% 1.31 1.12,2.61 <0.001 Fixed-effects model
CC vs. CA+AA 0.000 84.8% 1.26 1.16,1.71 <0.001 Random-effects model
Asia 6(2813/3124)
CC vs. CA 0.000 55.5% 1.17 1.01,1.41 <0.001 Random-effects model
CC vs. AA 0.000 38.4% 1.50 1.01,2.15 <0.001 Fixed-effects model
CA vs. AA 0.000 55.1% 1.38 1.03,1.87 <0.001 Random-effects model
CC vs. CA+AA 0.000 53.4% 1.21 1.06,1.75 <0.001 Random-effects model
Caucasian 7(1200/2195)
CC vs. CA 0.651 0.0% 1.01 0.90,1.13 0.878 Fixed-effects model
CC vs. AA 0.392 5.2% 1.04 0.89,1.21 0.937 Fixed-effects model
CA vs. AA 0.299 15.2% 1.07 0.92,1.45 0.430 Fixed-effects model
CC vs. CA+AA 0.180 29.9% 1.35 0.72,2.52 0.829 Fixed-effects model
rs1801018 5(1889/2110)
AA vs. AG+GG 0.088 43.6% 0.95 0.68,1.36 0.547 Fixed-effects model
AG vs. GG 0.610 0.0% 1.51 0.74,2.13 0.429 Fixed-effects model