Table 4. Meta-analysis of BCL-2 promoter polymorphisms and cancer prognosis.
Genetic model | No.ofstudies | PQ | I2 | HR | 95% CI | PZ | Model |
---|---|---|---|---|---|---|---|
rs2279115 | |||||||
Total | 13(4013/5319) | ||||||
CC vs. CA | 0.011 | 59.6% | 1.09 | 1.03,1.51 | <0.001 | Random-effects model | |
CC vs. AA | 0.018 | 58.5% | 1,18 | 1.07,1.66 | <0.001 | Random-effects model | |
CA vs. AA | 0.677 | 0.00% | 1.31 | 1.12,2.61 | <0.001 | Fixed-effects model | |
CC vs. CA+AA | 0.000 | 84.8% | 1.26 | 1.16,1.71 | <0.001 | Random-effects model | |
Asia | 6(2813/3124) | ||||||
CC vs. CA | 0.000 | 55.5% | 1.17 | 1.01,1.41 | <0.001 | Random-effects model | |
CC vs. AA | 0.000 | 38.4% | 1.50 | 1.01,2.15 | <0.001 | Fixed-effects model | |
CA vs. AA | 0.000 | 55.1% | 1.38 | 1.03,1.87 | <0.001 | Random-effects model | |
CC vs. CA+AA | 0.000 | 53.4% | 1.21 | 1.06,1.75 | <0.001 | Random-effects model | |
Caucasian | 7(1200/2195) | ||||||
CC vs. CA | 0.651 | 0.0% | 1.01 | 0.90,1.13 | 0.878 | Fixed-effects model | |
CC vs. AA | 0.392 | 5.2% | 1.04 | 0.89,1.21 | 0.937 | Fixed-effects model | |
CA vs. AA | 0.299 | 15.2% | 1.07 | 0.92,1.45 | 0.430 | Fixed-effects model | |
CC vs. CA+AA | 0.180 | 29.9% | 1.35 | 0.72,2.52 | 0.829 | Fixed-effects model | |
rs1801018 | 5(1889/2110) | ||||||
AA vs. AG+GG | 0.088 | 43.6% | 0.95 | 0.68,1.36 | 0.547 | Fixed-effects model | |
AG vs. GG | 0.610 | 0.0% | 1.51 | 0.74,2.13 | 0.429 | Fixed-effects model |