Table 2. Meta-analysis of the association between FGFR4 rs351855 G>A polymorphism and cancer risk.
| Variables | No. of studies | Homozygous | Heterozygous | Recessive | Dominant | Allele | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AA vs. GG | AG vs. GG | AA vs. AG/GG | AG/AA vs. GG | A vs. G | |||||||
| OR (95% CI) | Phet | OR (95% CI) | Phet | OR (95% CI) | Phet | OR (95% CI) | Phet | OR (95% CI) | Phet | ||
| All a | 27 | 1.19 (0.98-1.44) | <0.001 | 1.00 (0.91-1.10) | 0.012 | 1.19 (1.01-1.41) | <0.001 | 1.02 (0.91-1.13) | <0.001 | 1.07 (0.98-1.16) | <0.001 |
| Cancer type | |||||||||||
| Breast | 6 | 1.73 (1.35-2.20) | 0.960 | 1.17 (0.95-1.45) | 0.186 | 1.46 (1.17-1.83) | 0.986 | 1.25 (1.02-1.52) | 0.197 | 1.26 (1.14-1.41) | 0.622 |
| CRC | 3 | 0.84 (0.59-1.19) | 0.701 | 0.87 (0.72-1.06) | 0.964 | 0.89 (0.63-1.26) | 0.718 | 0.87 (0.72-1.04) | 0.895 | 0.90 (0.78-1.04) | 0.773 |
| Others | 7 | 1.25 (0.85-1.84) | 0.017 | 0.96 (0.81-1.14) | 0.290 | 1.30 (0.92-1.85) | 0.019 | 0.96 (0.77-1.18) | 0.040 | 1.09 (0.92-1.30) | 0.022 |
| Prostate | 6 | 1.60 (0.99-2.61) | 0.020 | 1.16 (1.02-1.32) | 0.714 | 1.56 (0.92-2.65) | 0.004 | 1.20 (1.06-1.35) | 0.892 | 1.22 (1.06-1.41) | 0.183 |
| Lung | 2 | 0.58 (0.40-0.83) | 0.231 | 0.75 (0.61-0.91) | 0.596 | 0.67 (0.53-0.85) | 0.388 | 0.70 (0.58-0.85) | 0.332 | 0.76 (0.67-0.86) | 0.358 |
| HCC | 3 | 1.08 (0.84-1.38) | 0.341 | 0.93 (0.68-1.28) | 0.127 | 1.09 (0.89-1.33) | 0.656 | 0.96 (0.73-1.28) | 0.139 | 1.02 (0.88-1.19) | 0.241 |
| Ethnicity | |||||||||||
| Caucasians | 14 | 1.05 (0.88-1.25) | 0.349 | 1.04 (0.95-1.13) | 0.497 | 1.02 (0.88-1.19) | 0.448 | 1.00 (0.89-1.12) | 0.116 | 1.03 (0.95-1.12) | 0.192 |
| Asians | 11 | 1.25 (0.90-1.73) | <0.001 | 0.96 (0.80-1.16) | 0.001 | 1.28 (0.99-1.66) | <0.001 | 1.03 (0.84-1.26) | <0.001 | 1.09 (0.93-1.28) | <0.001 |
| African | 2 | 2.17 (0.20-23.14) | 0.169 | 1.05 (0.61-1.80) | 0.322 | 2.21 (0.18-26.83) | 0.019 | 1.11 (0.66-1.86) | 0.617 | 1.15 (0.73-1.82) | 0.948 |
| Source of control | |||||||||||
| PB | 14 | 1.07 (0.90-1.27) | 0.365 | 1.00 (0.88-1.13) | 0.169 | 1.07 (0.92-1.25) | 0.409 | 0.99 (0.87-1.12) | 0.082 | 1.04 (0.96-1.12) | 0.343 |
| ND | 3 | 1.83 (1.30-2.56) | 0.175 | 1.30 (1.03-1.64) | 0.218 | 1.54 (1.08-2.22) | 0.088 | 1.44 (1.19-1.76) | 0.283 | 1.34 (1.14-1.58) | 0.170 |
| HB | 10 | 1.08 (0.77-1.51) | <0.001 | 0.92 (0.81-1.05) | 0.237 | 1.13 (0.84-1.50) | <0.001 | 0.96 (0.81-1.13) | 0.018 | 1.02 (0.87-1.18) | <0.001 |
Abbreviations: Het, heterogeneity; CRC, colorectal cancer; HCC, hepatocellular carcinoma; HB, Hospital based; PB, Population based; ND, not determined.