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. 2017 Mar 6;8(15):25362–25371. doi: 10.18632/oncotarget.15911

Table 5. Association between PON1 Q192R polymorphism genotype frequencies and clinic-pathological parameters of the breast cancer patients.

Age Menopausal BMI(kg/m2) Lymph node status AJCC stage
Premenopausal Postmenopausal ≤24.9 25.0-29.9 ≥30.0 N0 N1 I II III IV
ALL LL 50 ± 9 71(45.8) 84(54.2) 101(65.2) 43(27.7) 11(7.1) 63 (40.6) 92 (59.4) 4(2.6) 44 (28.4) 85 (54.8) 22 (14.2)
M 46 ± 9 124(59.0) 86(41.0) 141(67.1) 49(23.3) 20(9.5) 99 (47.1) 111 (52.9) 14(6.7) 69 (32.9) 93 (44.3) 34 (16.2)
P 0.413 0.103 0.395 0.859 0.326
Premenopausal LL 42 ± 6 41(58.6) 23(32.9) 6(8.6) 39 (55.7) 31 (44.3) 3(4.3) 19 (27.1) 36 (51.4) 12 (17.1)
M 40 ± 5 75(61.0) 38(30.9) 11(8.9) 78 (63.4) 45 (36.6) 12(9.8) 42 (34.1) 48 (39.0) 22 (17.9)
P 0.137 0.642 0.182 0.116
Postmenopausal LL 57 ± 5 60(71.4) 19(22.6) 5(6.0) 23 (27.4) 61 (72.6) 1(1.2) 24 (28.6) 49 (58.3) 10 (11.9)
M 56 ± 5 66(76.7) 11(12.8) 9(10.5) 20 (23.3) 66 (76.7) 2(2.3) 27 (31.4) 45 (52.3) 12 (14.0)
P 0.527 0.369 0.212 0.792
First-degree family history of breast cancer Ever been pregnant Smoking status Alcohol drinker Case by stage Estrogen Receptor(ER) status Progesterone Receptor(PgR) status
No Yes No Yes No Yes No Yes Local Advanced ER+ ER- PgR+ PgR-
ALL LL 147(94.8) 8(5.2) 147 (94.8) 8(5.2) 146 (94.2) 9 (5.8) 142 (91.6) 13 (8.4) 56 (36.1) 99(63.9) 48(31.0) 107 (69.0) 56 (36.1) 99(63.9)
M 200(95.2) 10(4.8) 203 (96.7) 7(3.3) 191 (91.0) 19 (9.0) 191 (91.0) 19 (9.0) 77 (36.7) 133(63.3) 57(27.1) 153 (72.9) 62 (29.5) 148(70.5)
P 0.828 0.297 0.664 0.296 0.421 0.882 0.364
Premenopausal LL 66(94.3) 4(5.7) 63 (90.0) 7(10.0) 62 (88.6) 8 (11.4) 59 (84.3) 11 (15.7) 39 (55.7) 31(44.3) 23(32.9) 47 (67.1) 30 (42.9) 40(57.1)
M 117(95.1) 7(5.7) 118 (95.9) 6(4.9) 106 (86.2) 18 (14.6) 108 (87.8) 16 (13.0) 64 (52.0) 60(48.8) 36(29.3) 88 (71.5) 39 (31.7) 85(69.1)
P 0.464 0.154 0.668 0.187 0.763 0.989 0.220
Postmenopausal LL 80(95.2) 4(4.8) 83 (98.8) 1(1.2) 83 (98.8) 1 (1.2) 81 (96.4) 3 (3.6) 16 (19.0) 68(81.0) 24(28.6) 60 (71.4) 24 (28.6) 60(71.4)
M 83(96.5) 3(3.5) 85 (98.8) 1(1.2) 85 (98.8) 1 (1.2) 83 (96.5) 3 (3.5) 13 (15.1) 73(84.9) 21(24.4) 65 (75.6) 23 (26.7) 63(73.3)
P 0.436 0.946 0.898 0.427 0.680 0.765 0.869

BMI, body mass index; AJCC, American joint committee on cancer.