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. 2017 Mar 9;8(15):25469–25481. doi: 10.18632/oncotarget.16038

Figure 5. C-MYC is a potential upstream regulator of TRIP13 in CLL.

Figure 5

Knowledge-based interaction network of c-MYC and c-MYC targets after TRIP13 knockdown in JVM-2. The network was built based on the c-MYC interactome in the Ingenuity IPA database overlaid with microarray data from cells with a 1.5-fold change cut-off. The intensity of the node color indicates the degree of up- (red) or down- (green) regulation following AK4 overexpression in JVM-2 cells.